ncRNA name | hsa-miR-23a |
ncRNA Category | miRNA |
Disease name | age-related macular degeneration (AMD) |
Species | Homo sapiens |
Tissues/Cell_line | human RPE cell line ARPE-19 |
Methods | MTT assay, luciferase reporter assay, transfection, qPCR, Western blot |
Expression pattern | up-regulated |
Functional description | This study illustrated a mechanism for the protection of the oxidative-induced RPE cell death through the recovery of glutamine metabolism by inhibition of miR-23a, contributing to the discovery of novel targets and the developments of therapeutic strategies for the prevention of RPE cells from oxidative stress. |
PubMed ID | 27411920 |
Year | 2016 |
Title | Inhibition of the oxidative stress-induced miR-23a protects the human retinal pigment epithelium (RPE) cells from apoptosis through the upregulation of glutaminase and glutamine uptake. |
Drug-related ncRNA | NO |
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